Temat: WITAM SERDECZNIE
Widze, ze cos slyszales o wplywie zielonej herbacie na poziom testosteronu ale wyciagasz zle wnioski.
Badanie, do ktorego zapewne sie odwolujesz
Modulation of endocrine systems and food intake by green tea
epigallocatechin gallate.
Kao YH, Hiipakka RA, Liao S.
Ben May Institute for Cancer Research, Department of Biochemistry and Molecular Biology, and Tang Center for Herbal Medicine Research, University of Chicago, Illinois 60637, USA.
Green tea polyphenols, especially the catechin, (-)-epigallocatechin gallate (EGCG), have been proposed as a cancer chemopreventative based on a variety of laboratory studies. For clear assessment of the possible physiological effects of green tea consumption, we injected pure green tea catechins ip into rats and studied their acute effects on endocrine systems. We found that EGCG, but not related catechins, significantly reduced food intake; body weight; blood levels of testosterone, estradiol, leptin, insulin, insulin-like growth factor I, lh - leutenizing hormone - , glucose, cholesterol, and triglyceride; as well as growth of the prostate, uterus, and ovary. Similar effects were observed in lean and obese male Zucker rats, suggesting that the effect of EGCG was independent of an intact leptin receptor. EGCG may interact specifically with a component of a leptin-independent appetite control pathway. Endocrine changes induced by parenteral administration of EGCG may relate to the observed growth inhibition and regression of human prostate and breast tumors in athymic mice treated with EGCG as well as play a role in the mechanism by which EGCG inhibits cancer initiation and promotion in various animal models of cancer.
Wyglada strasznie - spadek testosteonu, leptyny, igf-1. Ale jesli spojrzysz na pogrubiony fragment to zobaczysz, ze to glownie z powodu znacznie obnizonej ilosci przymowanego pozywienia. Takie zmiany hormonalne sa typowe dla bardzo nisko kalorycznych diet.
Zreszta badania sa rozne, to pokazuje, ze zielona herbata podnosi poziom testosteronu i obniza aktwnosc aromatazy
Food Chem Toxicol. 2002 Jul;40(7):925-33.
Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats.
Satoh K, Sakamoto Y, Ogata A, Nagai F, Mikuriya H, Numazawa M, Yamada K, Aoki N.
Department of Toxicology, The Tokyo Metropolitan Research Laboratory of Public Health, 24-1 Hyakunincho 3 chome, Shinjuku-ku, Japan. sato@tokyo-eiken.go.jp
We orally administered polyphenone-60 (P-60), green tea extract catechins, in the diet (0, 1.25 and 5%) to male rats for 2, 4 and 8 weeks initiated at 5 weeks old. It was found that a 5% dose to male rats for 2-8 weeks induced goiters and decreased weights of the body, testis and prostate gland. Endocrinologically, elevating plasma thyroid stimulating hormone (TSH), luteinizing hormone (LH) and testosterone levels and decreasing tri-iodothyronine (T(3)) and thyroxine (T(4)) levels were induced by this treatment. We also found that P-60 as a whole and some of its constituents exhibited inhibitory effects on human placental aromatase activity by in vitro assay. The concentration of P-60 that required producing 50% inhibition of the aromatase activity (IC(50) value) was 28 microg/ml. The IC(50) values of (-)-catechin gallate (Cg), (-)-epigallocatechin (EGC), (-)-epigallocatechin gallate (EGCg) and (-)-gallocatechin gallate (GCg) were 5.5 x 10(-6), 1.0 x 10(-4), 6.0 x 10(-5) and 1.5 x 10(-5) M, respectively. (-)- Epicatechin gallate (ECg) at 1.0 x 10(-4) M produced 20% inhibition. (-)-Epicatechin (EC) and (+)-catechin (CT) exhibited no effects on aromatase activity. The endocrinological changes observed in vivo were in conformity with antithyroid effects and aromatase inhibition effects of P-60 and its constituents.
Co do L-Karnityny to posluze sie cytatem z ksiazki "SPORTS
NUTRITION Energy Metabolism and Exercise"
"Research has addressed the question of whether there are physiologically feasible supplements that could increase lipid metabolism. One such supplement that has received attention is L-carnitine. In the body’s cells, carnitine is an important protein responsible for shuttling fatty acyl-coA across the inner mitochondrial membrane into the mitochondrial matrix to undergo oxidative metabolism. The enzymes that catalyze this reaction
are known collectively as carnitine acyl transferase 1, or CAT1.
12 When taken as a supplement, however, L-carnitine in the muscle has been shown to remain unchanged following supplementation, 13
and does not decrease following a single prolonged exercise session. 14 A recent study also concluded that L-carnitine taken as a supplement with exercise in untrained individuals does not have a positive effect on lipid metabolism. 15"
a badania do ktorych sie odwoluja to
12. Brooks, G.A., Fahey, T.D., White, T.P., and Baldwin, K.M. Exercise Physiology: Human Bioenergetics and Its Applications. (3rd ed.) Mountain View: Mayfield, 2000.
13. Vukovich, M.D., Costill, D.L., and Fink, W.J. Carnitine supplementation: Effect on muscle carnitine and glycogen content during exercise. Med Sci Sports Exer, 26:1122–1129, 1994.
14. Decombaz, P., Deriaz, O., Acheson, K., Gmuender, B., and Jequier, E. Effect of Lcarnitine on submaximal exercise metabolism after depletion of muscle glycogen. Med Sci Sports Exer, 25:733–740, 1993.
15. Lee, J.K., Lee, J.S., Park, H., Cha, Y-S, Yoon, C.S., and Kim, C.K. Effect of Lcarnitine supplementation and aerobic training on FABPc content and beta-HAD activity in human skeletal muscle. Eur J Appl Physiol 2006. [e-pub ahead of print].
Dla mnie jedyna warta uwagi forma L-Karnityny jest Acetyl-L-Karnityna z racji tego, ze w organizmie staje sie donorem reszt acetylowych /ktore moga byc uzyte w syntezie np. Acetylocholiny/
A reszty skladnikow sa tak male dawki, ze nawet nie ma co sobie nimi zawracac glowy. Dla przykladu skuteczna dzienna dawka lecytyny to 10-15g, choliny /zakladajac, ze to nie alfa-gpc ale jedna z tradycyjnych form/ 5-7g, inozytol 5-6g itd.
Mi by bylo szkoda wydac 60-70zl na cos takiego.
пропозиції роботи
